Cytochalasin D

A fungal metabolite that blocks cytoplasmic cleavage by blocking formation of contractile microfilament structures resulting in multinucleated cell formation, reversible inhibition of cell movement, and the induction of cellular extrusion. Additional reported effects include the inhibition of actin polymerization, DNA synthesis, sperm motility, glucose transport, thyroid secretion, and growth hormone release.

Also Known As:

(11)Cytochalasa- 6(12),13,19- triene- 1,17- dione, 21- (acetyloxy)- 7,18- dihydroxy- 16,18- dimethyl- 10- phenyl- , (7S,13E,16S,18R,19E,21R)-

Pharmalogical Action Categories:

Nucleic Acid Synthesis Inhibitors

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Cytochalasins: 40
        Cytochalasin D: 250
Biological Factors: 2472
- Biological Toxins: 20
  - Mycotoxins: 1745
    - Cytochalasins: 40
      - Cytochalasin D: 250

M E Derkacheva Selected Research

M E Derkacheva Research Topics

Disease

Drug/Important Bio-Agent (IBA)